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Current evidence indicates that LDL-C can be aggressively lowered with statin therapy regardless of baseline levels and suggests that there is no threshold below which LDL-C lowering ceases to be effective ( Grade A; BEL 1).

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In addition to diarrhea, joint pain and tiredness, patients have experienced severe muscle problems, especially when Zetia was added to complement the statin drug they were on.

An elevated LDL-cholesterol level is an established risk factor for heart disease and lowering cholesterol reduces the risk of death from heart disease and stroke.

The bottom line is: why take a combination of two drugs that has no clear health benefits compared to taking just one of the drugs?

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Zetia, administered with atorvastatin or simvastatin (40- and 80-mg statin groups, pooled), significantly reduced LDL-C (21%) compared with increasing the dose of simvastatin or atorvastatin monotherapy from 40 to 80 mg (7%).

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I already told you, this is an individualized therapy, and evolving therapy consisting of many drugs, and can only be compared with the natural course of the disease.

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Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a phase II reaction) with subsequent biliary and renal excretion.

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Zetia in addition to diet has been shown to help decrease total cholesterol and LDL (bad) cholesterol.

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Taken together with a preexisting concern regarding the clinical effectiveness of ezetimibe, our findings challenge the usefulness of LDL cholesterol reduction as a guaranteed surrogate of clinical efficacy, particularly reduction achieved through the use of novel clinical compounds.

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Diabetes is THE most common cause of peripheral neuropathy and its increased incidence in those who took statins probably means the patients are living with their diabetes longer BECAUSE of the statins.

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An enzyme, paraoxonase or PON1, has been found to help the High Density Lipoprotein (HDL) cholesterol in lowering cholesterol overall.

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The FDA Medical Officer conducting the Zetia safety review of clinical trials noted that patients taking Zetia were more likely to have elevations of a blood enzyme known as creatinine phosphokinase (CPK), an early signal of muscle toxicity and a risk factor for the possible development of rhabdomyolysis.

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Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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It is a key ingredient of bile, which in turn is needed for fat digestion, absorption of fat-soluble vitamins as well as the control of cholesterol serum levels in the body.

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Hacer esto es siempre importante cuando se tiene un medicamento, procedimiento o intervencin que resulta costoso en comparacin con la atencin estndar, dijo Nicole Mittmann, autora principal del estudio sobre Aromasin, cientfica del Centro de ciencias de la salud Sunnybrook y profesora adjunta de farmacologa de la Universidad de Toronto.

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